What is GAG-DB ?
This database contains the three-dimensional structures of Glycosaminoglycan (GAG) binding proteins that have been crystallized with their ligands. The type of proteins, along with the bound GAG are provided. Links are available to access the information about the original article (Medline), the protein sequence, related structural information (Swissprot, PDB) ....
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C-4S
4N8W
Hedgehog morphogen
4C4M
Polysaccharide lyase 8
2WDA
Chodroitin Sulfate
Unsaturated glucuronyl hydrolase
2AHG
Chondroitin
Chondroitin 4 Sulphate
2KQO
Chondroitin Sulfate
2C4S
CHONDROITIN-4-SULFATE
1C4S
Chondroitinase AC (A. aurescens)
1RWC
Chondroitin Sulfate
1RWF
Chondroitin Sulfate
1RWG
1RWH
Chondroitinase AC (F. heparinus)
1HMW
Chondroitinase B. (P. heparinus)
1OFM
FMDV-receptor
1QQP
Hayluronase (S. pneumonia)
1OJM
1OJP
Hyaluronase mutant (S. pneumonie)
1OJN
1OJO
CS4
Cathepsin K
3C9E
Cathepsin K mutant
3H7D
CS6
Unsaturated glucuronyl hydrolase (mutant)
3ANK
deCS
Unsaturated rhamnogalacturonyl hydrolase
2D8L
Dermatan Sulfate
Chondroitinase B. (P. heparinus)
1OFL
DS
4N79
Chondroitinase AC (F. heparinus)
1HM2
1HMU
Chondroitinase B (B. heparinus)
1DBO
HA
4MRD
CD44
2JCR
Chondroitinase AC (F. heparinus)
1HM3
Hayluronase (S. pneumonia)
1C82
Hyaluronase (bee venom)
1FCV
Hyaluronidase (S. coelicolor)
2WCO
HE
ECP
2LVZ
NK1 (HGF)
1GMO
Protease nexin-1
4DY0
Protein C inhibitor
3DY0
Heparin
3-0-Sulfotransferase (H. sapiens)
1T8U
Annexin 2A
2HYU
2HYV
Annexin V
1G5N
Anti-thrombin-III
1NQ9
Anti-thrombin-III/Thrombin
1TB6
Antithrombin III mutant
2GD4
Cobra
1XT3
EMPB
2BRS
FGF-1
2AXM
FGF-2/FGR-1
1FQ9
heparin
3IRI
Heparin
3IRJ
3IRK
3IRL
Heparinase II (P. Heparinus)
2FUT
NK1 (HGF)
1GMN
RANTES
1U4L
1U4M
Thrombin
1XMN
Thrombospondin 1
1ZA4
Heparin Analog
FGF
2ERM
Heparin Mimetics
Anti-thrombin-III
1SR5
Heparin-like
2B5T
HP
4NDZ
4PXQ
4QFJ
4RDA
4UYW
5D65
5DNF
5E9C
5T05
5UE2
5W1O
5W1X
3-O-sulfotransferase (M. musculus)
3UAN
Anti-thrombin-III
1AZX
1E03
Antithrombin-factor Ixa
3KCG
BT4661, aSuse-like surface polysaccharide bin
4AK2
C1q
2WNU
E2 domain of APLP1
3QMK
ECP
2NWG
FGF-1
1AXM
3UD7
3UD8
3UD9
3UDA
FGF-1.FGR-1c
3OJV
FGF-2
1BFB
1BFC
FGF-2/FGR-1
1E0O
HE/HS sensing hybrid component system BT4663
4A2M
Hedgehog morphogen
4C4N
Heparinase I (B. thetalotaomicron)
3ILR
3IN9
Heparinase I mutant (B. thetalotaomicron)
3INA
Peptidoglycan recognition protein-S
3OGX
Protein C inhibitor
3B9F
VFT2
3MKP
HS
5E98
5E9B
5T03
5T0A
Antithrombin III
3EVJ
Heparinase II (P. Heparinus)
3E80
Heparinase II mutant (P. Heparinus)
3E7J
Hyaluronan
Hyaluronan
1HUA
2BVK
Hyaluronic Acid
CD44
2JCQ
Hyaluronase (S. agalactiae)
1I8Q
1LXK
1LXM
Hyaluronase mutant (S. pneumonie)
1N7Q
1N7R
Hyaluronate Lyase
1LOH
Hyaluronic Acid
1HYA
3HYA
4HYA
Keratan Sulfate
Keratan sulfate
1KES
Other
Vaccine Complement Protein
1HPN
Sucrose 8sulfate
2UUS
2V5E
3LDJ
3QRC
What are GAGs ?
Glycosaminoglycans are linear, anionic polysaccharides, (GAGs) consisting of repeating disaccharides. Indeed, most GAG chains are formed from repeating disaccharide units of hexosamine and hexuronic acid. The exception is keratan sulfate, whose building blocks consist of hexosamine and galactose. Differences in the structure of the primary disaccharide unit regarding types of uronic acid and hexosamine, the number and position of the sulphate residues, the presence of N-acetyl and/or N-sulphate groups and the relative molecular mass. All such differences bestow these biomolecules' impressive complexity and diversity. The fine structure of the disaccharide units defines the types of GAGs. These include chondroitin/dermatan sulfate (CS/DS), heparin/heparan sulfate (Hep/HS), keratan sulfate (KS) as well as the non-sulfated hyaluronan (HA). GAGs are ubiquitously localized throughout the extracellular matrix (ECM) and to the cell membranes of cells in all tissues. They are either conjugated to protein cores in the form of proteoglycans, e.g., CS/DS, HS, and KS or as free GAGs (HA and Hep). Through their interaction with proteins, GAGs can affect cell-ECM and cell-cell interactions finely modulating ligand-receptor binding and thus chemokine and cytokine activities as well as growth factor sequestration. Indeed, it is well established that GAGs participate in the regulation of all biological processes under homeostasis; they also participate in disease progression.